Tourette syndrome (TS) is a neuropsychological disorder that is related to OCD, and is characterized by sudden, repetitive movements and/or sounds called tics. Some people with OCD also experience tics, leading to a condition known as tic-related OCD. This combination of symptoms presents unique challenges, as the distinction between OCD-related compulsions and tics can be difficult. People with tic-related OCD are usually younger when the symptoms start, present very specific OCD symptoms, and more men than women are affected. People with tic-related OCD may experience unique challenges in treatment effectiveness compared to those with OCD or TS alone. What sets these individuals with tic-related OCD apart from those with only OCD or TS?

This study will explore if OCD with tics is different from OCD without tics in terms of genetics. Large sets of genetic data from people with OCD, TS or both disorders will be analyzed to find similarities and differences of genes in these groups. The aim is to explore whether there are specific genetic patterns for people with tic-related OCD compared to those with only OCD or TS. The study will also look at how these patterns relate to other conditions, like attention-deficit hyperactivity disorder or autism. By understanding these genetic differences, better ways to diagnose and personalize the treatment of OCD, TS, and their combination could be developed.