PANDAS/PANS is associated with neuroinflammation that leads to sudden and acute OCD symptoms developing in children, seemingly overnight. Non-steroidal anti-inflammatory drugs (NSAIDs) like celecoxib (brand name “Celebrex”) are increasingly recommended… Read more »
Circadian rhythm changes as a predictor of OCD symptom severity and outcome in residential treatment
Problems with sleep — in particular a delayed sleep cycle where a person falls asleep late at night and wakes up in the late morning or early afternoon — have… Read more »
Intervening on loneliness to reduce object attachment in hoarding disorder: Two randomized controlled pilot studies
People with hoarding disorder (HD) experience strong emotional attachment to their possessions, and extreme difficulty and distress when throwing things away. This can lead to excessive collecting of possessions, with… Read more »
Understanding and treating OCD in older adults
With the population aging globally, the number of older adults with OCD is expected to double within the next 30 years. We currently lack important information about the best possible… Read more »
Using a machine learning approach to identify immune biomarkers associated with PANS/PANDAS
Despite recent research into Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS) and Pediatric Autoimmune Neuropsychiatric Syndrome (PANS), clinicians and researchers often struggle to differentiate childhood OCD and PANDAS/PANS. These… Read more »
Waxing and waning: Using ecological momentary assessment to assess chronotype as a potential mechanism of within-day obsessive-compulsive disorder symptom fluctuations
Prior research has suggested links between a person’s sleep habits, their biological clock (circadian rhythm), and OCD symptoms. Many people with OCD report that their symptoms are better or worse… Read more »
Beyond the Goal versus Habit binary: A computational EEG Study of the neurocognitive mechanisms of obsessive compulsive disorder
In order to better understand OCD, researchers are investigating what happens in the brain when people with OCD perform compulsions. Research shows that in OCD, the parts of the brain… Read more »
Correlates of treatment outcome using multimodal neuroimaging in children with PANDAS
Researchers are increasingly interested in the connection between inflammation in the brain and OCD symptoms in both Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS) and more typical childhood-onset… Read more »
Developing a cultural adaptation toolkit to increase equity for underserved youth with obsessive-compulsive and related disorders
While many effective treatments for OCD have been developed through research, most of the studies used did not include diverse groups of research participants. This lack of diversity led to… Read more »
Optimization of parent-led exposure delivery in pediatric OCD
When children develop OCD, the most effective treatment available for them is cognitive behavioral therapy (CBT) with exposure and response prevention (ERP). Children engage in exposure work where they intentionally… Read more »