2002 OCF Grant

Cytochrome p450 2D6 polymorphisms/duplications and serotonin uptake inhibitor response in OCD: A pilot study

Stefanie Schwartz, PhD & John Black, MD

Mayo Clinic (Rochester, MN)

Award Amount: $25,000

At the time of this study, serotonin reuptake inhibitors (SRIs) only benefited about 60% of patients who took them for OCD; even then, response was usually partial. 

This study by Drs. Schwartz and Black aimed to investigate whether there was a genetic abnormality in some people with OCD that caused the rapid metabolism of SRIs, and whether this was linked to the low effect these medications had on symptoms for them.