2006 OCF Grant

Genetic studies of the NMDA regulatory network in OCD including neuroimaging endophenotypes

Paul Arnold, MD

Centre for Addiction and Mental Health (Toronto, Ontario, Canada)

Award Amount: $48,193

With growing interest in how glutamate (one of the most important neurotransmitters linked to learning, memory, and mood) and N-methyl-D-aspartate (NMDA; a glutamate receptor in the brain) are connected to OCD, studies continued to explore how these factors impact OCD symptoms and how related treatments could be created.

This study by Dr. Arnold and his team aimed to use magnetic resonance imaging (MRI) to investigate genetic factors tied to NMDA associated with early-onset OCD (appearing before age 15).