Although cognitive behavior therapy (CBT) has shown to be effective for treating children with OCD, not everyone responds to this treatment. As a result, factors that could help make patients… Read more »
Augmentation of behavioral exposure therapy for obsessive compulsive disorder with D-Cycloserine
While exposure and response prevention (ERP) and cognitive behavioral therapy (CBT) are effective for treating OCD, some patients do not experience a reduction in symptoms. In animal models, d-cycloserine has… Read more »
Cytokine production in patients with OCD
Chronic and prolonged stress coupled with a long period of grief and despair can lead to an increased vulnerability to illness through their effects on the immune system. As a… Read more »
Cerebral metabolic predictors of response to paroxetine and risperidone in refractory obsessive compulsive disorder
Positron emission tomography (PET; body scans that measure changes in metabolic processes, blood flow, and other processes) scans have shown increased glucose metabolic rates in the brains of OCD patients,… Read more »
Psychobiology and treatment of SSRI-resistant obsessive compulsive disorder
Although selective serotonin reuptake inhibitors (SSRIs) are an effective treatment option for patients with OCD, research at the time showed that patients experienced a 40-60% reduction in symptoms. 30-40% of… Read more »
Single vs. combined pharmacological treatment of children and adolescents with comorbid OCD plus TS
Clinical trials performed for FDA registration for OCD in youth typically excluded youth with comorbid conditions. Notably, many young people have both OCD and Tourette syndrome or OCD and ADHD…. Read more »
Open-label trial of St. John’s wort (Hypericum perforatum) in obsessive compulsive disorder
St. John’s wort (Hypericum perforatum) is a plant that has been traditionally used in Europe to treat depression, with research demonstrating that it can act like a selective serotonin reuptake… Read more »
Adrenal enzyme disorders define a subtype of OCD that responds to a unique treatment
A risk factor that can predispose some individuals to develop OCD is a group of inherited adrenal gland enzyme disorders that affect the body’s steroid hormone production. Despite the effects… Read more »
A double-blind placebo-controlled trial of tramadol in treatment-refractory OCD
Although selective serotonin reuptake inhibitors (SSRIs) are a treatment for OCD, research at the time of this study showed that 40-50% of OCD patients experienced small or no symptom reduction… Read more »
Functional neuroanatomy of obsessive compulsive hoarding
This study was conducted before hoarding disorder (HD) became a separate diagnosis in the DSM-V in 2013. At the time of the study, research showed that 30% of OCD patients… Read more »