Although neuroimaging has generated insights into which brain regions are thought to be affected in people with OCD, the underlying cellular and molecular changes are still unknown. Using brain tissue… Read more »
Identifying the molecular and cellular substrates of OCD using human post-mortem brain
Brain imaging studies in OCD patients have consistently shown abnormal activity in regions involved in decision-making (orbitofrontal cortex [OFC]) and transmission of sensory information (thalamus). However, we have no knowledge… Read more »
Pilot study of the glutamate AMPAR modulator RR-HNK in OCD
Although there are medications that can help people with OCD manage their symptoms, those that are currently available may take up to two to three months to begin working. Additionally,… Read more »
Clinical trial of image-guided low-intensity focused ultrasound pulsation (LIFUP) for the treatment of obsessive compulsive disorder (OCD)
About one in three people with OCD do not get better after trying first-line treatments. For patients with severe, treatment-resistant OCD, Deep Brain Stimulation (DBS) is an effective option, but… Read more »
A precision medicine approach to OCD treatment: Targeting neuroinflammation
Much prior research has found evidence of brain inflammation’s role in the development of OCD. As a result, anti-inflammatory medications have been suggested as a potential avenue for treating symptoms… Read more »
Identifying targets for prevention and early intervention in Obsessive-Compulsive Disorder
Research has found that the risk for developing OCD is not only due to the genes we inherit from our parents, but also from environmental factors. However, it is unclear… Read more »
CBT augmentation to promote medication discontinuation in pediatric OCD
Several treatments have shown efficacy for treating pediatric OCD: cognitive behavioral therapy (CBT), medication with a serotonin reuptake inhibitor (SRI), and their combination (SRI+CBT). Although best practice suggests using CBT… Read more »
Neural mechanisms of active avoidance in obsessive compulsive disorder
According to behavioral models of OCD, compulsions are avoidance behaviors that alleviate distress from obsessions in the short term. Over time, this reinforces beliefs that obsessions are intolerable and that… Read more »