With the population aging globally, the number of older adults with OCD is expected to double within the next 30 years. We currently lack important information about the best possible… Read more »
Using a machine learning approach to identify immune biomarkers associated with PANS/PANDAS
Despite recent research into Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS) and Pediatric Autoimmune Neuropsychiatric Syndrome (PANS), clinicians and researchers often struggle to differentiate childhood OCD and PANDAS/PANS. These… Read more »
Waxing and waning: Using ecological momentary assessment to assess chronotype as a potential mechanism of within-day obsessive-compulsive disorder symptom fluctuations
Prior research has suggested links between a person’s sleep habits, their biological clock (circadian rhythm), and OCD symptoms. Many people with OCD report that their symptoms are better or worse… Read more »
Beyond the Goal versus Habit binary: A computational EEG Study of the neurocognitive mechanisms of obsessive compulsive disorder
In order to better understand OCD, researchers are investigating what happens in the brain when people with OCD perform compulsions. Research shows that in OCD, the parts of the brain… Read more »
Correlates of treatment outcome using multimodal neuroimaging in children with PANDAS
Researchers are increasingly interested in the connection between inflammation in the brain and OCD symptoms in both Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS) and more typical childhood-onset… Read more »
Developing a cultural adaptation toolkit to increase equity for underserved youth with obsessive-compulsive and related disorders
While many effective treatments for OCD have been developed through research, most of the studies used did not include diverse groups of research participants. This lack of diversity led to… Read more »
Optimization of parent-led exposure delivery in pediatric OCD
When children develop OCD, the most effective treatment available for them is cognitive behavioral therapy (CBT) with exposure and response prevention (ERP). Children engage in exposure work where they intentionally… Read more »
Elucidating the role of RXRɑ factor in myeloid cells for immune-mediated mechanisms of OCD
PANDAS may be associated with a form of basal ganglia encephalitis (BGE) caused by repetitive Group A Streptococcus (GAS) infections. Findings show that the immune response targeting repetitive GAS infections… Read more »
A modifiable transcriptomic signature of immune dysfunction in pediatric obsessive compulsive disorder (OCD)
Research shows that many children with PANS have dysfunctional immune systems. When conventional psychiatric medications fail, treatments such as intravenous immunoglobulin (IVIG) have shown some success; however, IVIG is short-term,… Read more »
Examining circadian and non-circadian phenotypes in obsessive compulsive disorder with delayed bedtimes
Relapse rates following OCD treatment are 50%, suggesting the existence of unidentified and untreated mechanisms in OCD. One of these mechanisms relates to circadian rhythm – the body’s biological clock…. Read more »