Although group A beta-hemolytic streptococcal (GABHS) infections typically cause symptoms such as “strep throat”, research at the time began to look at their connection to PANDAS — the sudden onset… Read more »
A systematic investigation of intensive residential management for severe obsessive compulsive disorder: Predictors of short and long-term outcome
At the time of this study, intensive residential treatment (IRT; a therapy module for severe, treatment-resistant OCD) was recently developed and showed promise for treating serious OCD. Multiple studies by… Read more »
The effects of brief consultation to families of OCD treatment refusers: A pilot outcome study
Although multiple treatment modalities can reduce or remove OCD symptoms, some people with OCD refuse to engage in them. This can be for a variety of reasons, including uncertainty or… Read more »
Clinical and genetics studies of OCD with and without tics
At the time of this study, a key focus of research was exploring the genetics behind OCD and its comorbidities. Genetic association studies were conducted to look at how certain… Read more »
Multi-site study of CBT treatment failures
Cognitive behavioral therapies (CBT) are a group of evidence-based treatments for OCD, including cognitive therapy, behavioral therapy, exposure and response prevention therapy (ERP). Despite their overall efficacy, some people with… Read more »
T-cell characterization after Streptococcal M-protein inoculation and superantigen administration: A role for superantigens in neuropsychiatric disorders
One angle of research into PANDAS/PANS looked at Group A Streptococcus — the bacteria responsible for strep throat infections that cause neuroinflammation and the development of OCD symptoms in some… Read more »
Genetic studies of the glutamate system in childhood OCD including gene interaction
At the time of this study, interest in the genetic factors behind OCD was high, with some evidence from neuroimaging and animal studies pointing to the role of genes affecting… Read more »
Family genetic studies of obsessive compulsive disorder
As genetic studies of OCD continued to gain interest, some researchers focused on genetic data collected from families of people with OCD. This study by Dr. Mathews and her team… Read more »
Adjunctive glycine for OCD
Although medications for OCD such as serotonin reuptake inhibitors (SRIs) have shown to be effective in reducing symptoms, some patients with OCD experience little reduction. OCD is associated with hyperactivity… Read more »
Measuring the effects of cognitive behavioral treatment on neurochemical compounds in pediatric OCD utilizing proton magnetic resonance spectroscopy
One of the theories behind why OCD occurs was that cortico-striatal dysfunctions in the brain were associated with symptoms. This study by Drs. Whiteside and Port aimed to investigate whether… Read more »