Although neuroimaging has generated insights into which brain regions are thought to be affected in people with OCD, the underlying cellular and molecular changes are still unknown. Using brain tissue… Read more »
Is tic-related OCD genetically different from OCD without tics?
Tourette syndrome (TS) is a neuropsychological disorder that is related to OCD, and is characterized by sudden, repetitive movements and/or sounds called tics. Some people with OCD also experience tics,… Read more »
Obsessive compulsive disorder and Tourette syndrome: Phenotype/genotype studies to disentangle their etiology
Previous research during the time of this study showed that OCD and Tourette syndrome (TS) may share common genetic characteristics. Despite these genes being associated with both OCD and TS,… Read more »
Genome-wide association of OCD in an isolated population
As part of ongoing research into the genetics behind OCD, this study by Dr. Knowles and his team aimed to collect and analyze DNA from a specific population — Afrikaners… Read more »
Are children of adults with OCD at greater risk? Investigating the genetics of OCD
At the time of this grant, research into genetic factors underlying OCD and its comorbidities was still novel. The team led by Drs. Black and Gaffney investigated whether children of… Read more »
A molecular genetic analysis of early-onset obsessive compulsive disorder
At the time of this grant, interest in research on the genetic basis of OCD was growing. With greater understanding of the roles that specific genetic variants play in the… Read more »
Obsessive compulsive disorder in a genetically homogenous population
Some research into the genetics behind OCD attempted to find specific genes that would serve as markers for the disorder. At the time of this study, different expression of the… Read more »
A family genetics study of children and adolescents with OCD
Research about the genetics of OCD and related disorders continued to thrive, as scientists sought the basic biological markers that could contribute to OCD developing. Family studies—involving patients and their… Read more »
Relation of the serotonin transporter gene to OCD
At the time of this study, interest in the role of the serotonin transporter gene regarding OCD was high. Research looking at the role of the gene showed mixed findings,… Read more »
Cytochrome p450 2D6 polymorphisms/duplications and serotonin uptake inhibitor response in OCD: A pilot study
At the time of this study, serotonin reuptake inhibitors (SRIs) only benefited about 60% of patients who took them for OCD; even then, response was usually partial. This study by… Read more »