At the time of this study, serotonin reuptake inhibitors (SRIs) only benefited about 60% of patients who took them for OCD; even then, response was usually partial. This study by… Read more »
Clinical and genetics studies of OCD with and without tics
At the time of this study, a key focus of research was exploring the genetics behind OCD and its comorbidities. Genetic association studies were conducted to look at how certain… Read more »
T-cell characterization after Streptococcal M-protein inoculation and superantigen administration: A role for superantigens in neuropsychiatric disorders
One angle of research into PANDAS/PANS looked at Group A Streptococcus — the bacteria responsible for strep throat infections that cause neuroinflammation and the development of OCD symptoms in some… Read more »
Genetic studies of the glutamate system in childhood OCD including gene interaction
At the time of this study, interest in the genetic factors behind OCD was high, with some evidence from neuroimaging and animal studies pointing to the role of genes affecting… Read more »
Family genetic studies of obsessive compulsive disorder
As genetic studies of OCD continued to gain interest, some researchers focused on genetic data collected from families of people with OCD. This study by Dr. Mathews and her team… Read more »
Cytokine levels and genes in childhood OCD: A longitudinal study
PANDAS/PANS creates symptoms of OCD that can wax and wane over time. Research at the time showed that patients with PANDAS/PANS are more likely to respond to medications and cognitive… Read more »
Genetic studies of the NMDA regulatory network in OCD including neuroimaging endophenotypes
With growing interest in how glutamate (one of the most important neurotransmitters linked to learning, memory, and mood) and N-methyl-D-aspartate (NMDA; a glutamate receptor in the brain) are connected to… Read more »
Candidate gene study of obsessive compulsive disorder in a US sample
Interest in finding key candidate genes that are associated with the development of OCD was high, as it could help with identifying OCD before it begins and inform treatment. This… Read more »
Genomic copy number variation in obsessive compulsive disorder
Research interest into the genetics behind OCD continued, especially regarding what can be found within the human genome (the full set of genetic information). This study by Dr. Simen and… Read more »
Predicting medication response in obsessive compulsive disorder
A variety of medications exist for OCD, such as selective serotonin reuptake inhibitors (SSRIs) and antidepressants such as clomipramine. However, not all patients respond to these medications equally, with some… Read more »