Research into twins and families demonstrated that OCD is highly heritable, and that OCD is linked to malfunctioning synapses (gaps between neurons through which information and neurotransmitters flow) in the… Read more »
Replication of genome-wide association findings of OCD
The International OCD Foundation Genetics Collaborative, a multi-national group established to discover genetic variation predisposing to OCD, has conducted the most extensive genetic study of OCD to date (half a… Read more »
Identifying the molecular and cellular substrates of OCD using human post-mortem brain
Brain imaging studies in OCD patients have consistently shown abnormal activity in regions involved in decision-making (orbitofrontal cortex [OFC]) and transmission of sensory information (thalamus). However, we have no knowledge… Read more »
Identifying targets for prevention and early intervention in Obsessive-Compulsive Disorder
Research has found that the risk for developing OCD is not only due to the genes we inherit from our parents, but also from environmental factors. However, it is unclear… Read more »
Expanding the genetic landscape of pediatric OCD
While the role of genetic factors in the development of OCD has been emphasized through research, more attention is needed to identify specific risk factors and underlying biological pathways. Past… Read more »
Dissecting the temporal and causal relationships between OCD and bipolar disorder
Compared to the general population, people with OCD are 10 times more likely to have a bipolar disorder (BPD) diagnosis. Research has shown that BPD comorbidity is associated with more… Read more »