While medications and psychotherapy can each help about 60% of OCD patients, troubling symptoms can often persist even among treatment responders. New therapeutic strategies are urgently needed. The top therapeutic… Read more »
Decision-making impairments in OCD: An integrated behavioral economics model
Patients with OCD often view risky situations as aversive, with high rates of avoidance of feared situations and stimuli (e.g., public restrooms, kitchen stoves). However, the research on risk aversion… Read more »
Active avoidance of threat cues and fear extinction in obsessive compulsive disorder
Past research has shown that we can learn to be afraid of things that we encounter, and that we can also modify our fears through exposure. New research has shown… Read more »
Neural mechanisms of avoidance in exposure and response prevention for OCD
Many patients with OCD who successfully complete ERP treatment experience life-changing improvements in their OCD symptoms. However, as many as 40-50% of patients do not experience a significant recovery. Dr…. Read more »
Celecoxib as an adjunct to treatment as usual in childhood-onset OCD: A double-blind randomized controlled trial
PANDAS/PANS is associated with neuroinflammation that leads to sudden and acute OCD symptoms developing in children, seemingly overnight. Non-steroidal anti-inflammatory drugs (NSAIDs) like celecoxib (brand name “Celebrex”) are increasingly recommended… Read more »
Circadian rhythm changes as a predictor of OCD symptom severity and outcome in residential treatment
Problems with sleep — in particular a delayed sleep cycle where a person falls asleep late at night and wakes up in the late morning or early afternoon — have… Read more »
Towards optimal use of internet-delivered interventions for obsessive compulsive disorder
Cognitive behavioral therapy (CBT), including exposure and response prevention (ERP), is a proven and effective treatment for obsessive-compulsive disorder (OCD). However, many people with OCD are unable to access effective… Read more »
Pilot study of the glutamate AMPAR modulator RR-HNK in OCD
Although there are medications that can help people with OCD manage their symptoms, those that are currently available may take up to two to three months to begin working. Additionally,… Read more »
Clinical trial of image-guided low-intensity focused ultrasound pulsation (LIFUP) for the treatment of obsessive compulsive disorder (OCD)
About one in three people with OCD do not get better after trying first-line treatments. For patients with severe, treatment-resistant OCD, Deep Brain Stimulation (DBS) is an effective option, but… Read more »
Understanding and treating OCD in older adults
With the population aging globally, the number of older adults with OCD is expected to double within the next 30 years. We currently lack important information about the best possible… Read more »