Although effective treatments for OCD exist, more than half of people with OCD never receive the care they need, especially if they have financial challenges. Caregivers, who play a critical… Read more »
Controlled evaluation of positive family interaction therapy (P-FIT) for children and adolescents with OCD
Dr. Piacentini and his team’s prior research identified poor family cohesion, high conflict, and high blame as significant obstacles to youths with OCD responding to exposure-based CBT. Notably, 92% of… Read more »
Monoclonal D8/17 positivity: A possible peripheral marker for some forms of OCD
Sydenham’s chorea is a type of rheumatic fever that may result from infections like strep throat, and which shares symptoms with OCD and Tourette syndrome. Previous research showed that an… Read more »
A molecular genetic analysis of early-onset obsessive compulsive disorder
At the time of this grant, interest in research on the genetic basis of OCD was growing. With greater understanding of the roles that specific genetic variants play in the… Read more »
Psychobiology and treatment of SSRI-resistant obsessive compulsive disorder
Although selective serotonin reuptake inhibitors (SSRIs) are an effective treatment option for patients with OCD, research at the time showed that patients experienced a 40-60% reduction in symptoms. 30-40% of… Read more »
Single vs. combined pharmacological treatment of children and adolescents with comorbid OCD plus TS
Clinical trials performed for FDA registration for OCD in youth typically excluded youth with comorbid conditions. Notably, many young people have both OCD and Tourette syndrome or OCD and ADHD…. Read more »
Cognitive behavioral treatment for obsessive thoughts among adolescents
OCD creates long term costs for patients who develop it early on, and beginning treatment early on in adolescence is crucial for better outcomes in the future. This study by… Read more »
A family genetics study of children and adolescents with OCD
Research about the genetics of OCD and related disorders continued to thrive, as scientists sought the basic biological markers that could contribute to OCD developing. Family studies—involving patients and their… Read more »
Genetic studies of the glutamate system in childhood OCD including gene interaction
At the time of this study, interest in the genetic factors behind OCD was high, with some evidence from neuroimaging and animal studies pointing to the role of genes affecting… Read more »
Evaluation of exposure and response prevention with or without parent management training for children with obsessive compulsive disorder and disruptive behavior
Although pediatric OCD presents its own difficult symptoms, prior research showed that almost half of children with OCD also had a comorbid disruptive behavior disorder. This study by Dr. Sukhodolsky… Read more »