OCD has been hypothesized to involve difficulty inhibiting thoughts and behaviors. Prior research has suggested that the brain’s frontal-striatal-thalamic-cortical (FSTC) circuitry plays an important role in regulating behavior, including inhibitory… Read more »
A family genetics study of children and adolescents with OCD
Research about the genetics of OCD and related disorders continued to thrive, as scientists sought the basic biological markers that could contribute to OCD developing. Family studies—involving patients and their… Read more »
Developing a cognitive rehabilitation program for OCD
Although cognitive behavioral therapy (CBT) and medication can help alleviate OCD symptoms in most, some individuals with OCD may not benefit fully. Additionally, individuals with OCD frequently report concerns about… Read more »
Relation of the serotonin transporter gene to OCD
At the time of this study, interest in the role of the serotonin transporter gene regarding OCD was high. Research looking at the role of the gene showed mixed findings,… Read more »
Cognitive-behavior therapy for comorbid OCD and major depression
Major depressive disorder is a common co-occurring condition with OCD; based on research at the time of the study, 30% of OCD patients also suffered from symptoms of depression. Cognitive… Read more »
Home-based versus office-based behavioral treatment of obsessive compulsive disorder
Given the overall efficacy of exposure and response prevention (ERP) therapy in treating OCD, evaluating whether ERP could be effective at home and familiar settings — where symptoms typically occur… Read more »
The effectiveness of cognitive-behavioral treatment for obsessive compulsive disorder: Do symptom-based subgroups respond differently?
At the time of this study, much research was dedicated to identifying distinct subtypes of OCD. This study by Dr. Calamari and his team intended to test whether there are… Read more »
Cytochrome p450 2D6 polymorphisms/duplications and serotonin uptake inhibitor response in OCD: A pilot study
At the time of this study, serotonin reuptake inhibitors (SRIs) only benefited about 60% of patients who took them for OCD; even then, response was usually partial. This study by… Read more »
Compulsive hoarding among elderly people
Hoarding disorder (HD) was considered to be a subtype of OCD until the publication of the DSM-5 in 2013. At the time of this study, relatively little was known about… Read more »
The effects of cognitive behavioral treatment on neurochemical compounds in patients with OCD: Evaluation of proton magnetic resonance spectroscopy
Although the initial plan of this study by Dr. Whiteside and his team was to understand the treatment effects of cognitive behavioral therapy and medication on OCD through the use… Read more »