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Genetic studies of the glutamate system in childhood OCD including gene interaction
At the time of this study, interest in the genetic factors behind OCD was high, with some evidence from neuroimaging and animal studies pointing to the role of genes affecting… Read more »
Family genetic studies of obsessive compulsive disorder
As genetic studies of OCD continued to gain interest, some researchers focused on genetic data collected from families of people with OCD. This study by Dr. Mathews and her team… Read more »
Adjunctive glycine for OCD
Although medications for OCD such as serotonin reuptake inhibitors (SRIs) have shown to be effective in reducing symptoms, some patients with OCD experience little reduction. OCD is associated with hyperactivity… Read more »
Measuring the effects of cognitive behavioral treatment on neurochemical compounds in pediatric OCD utilizing proton magnetic resonance spectroscopy
One of the theories behind why OCD occurs was that cortico-striatal dysfunctions in the brain were associated with symptoms. This study by Drs. Whiteside and Port aimed to investigate whether… Read more »
Evaluation of exposure and response prevention with or without parent management training for children with obsessive compulsive disorder and disruptive behavior
Although pediatric OCD presents its own difficult symptoms, prior research showed that almost half of children with OCD also had a comorbid disruptive behavior disorder. This study by Dr. Sukhodolsky… Read more »
Treatment response in OCD to sertraline and aripiprazole as compared to sertraline and placebo
Although selective serotonin reuptake inhibitors (SSRIs) are effective for treating OCD, they do not reduce OCD symptoms for everyone due to a variety of factors. A potential avenue of boosting… Read more »
Cytokine levels and genes in childhood OCD: A longitudinal study
PANDAS/PANS creates symptoms of OCD that can wax and wane over time. Research at the time showed that patients with PANDAS/PANS are more likely to respond to medications and cognitive… Read more »
Improving treatment outcome in obsessive compulsive disorder: Does a motivational enhancement intervention boost efficacy?
Despite the efficacy of exposure and response prevention (ERP) in treating OCD, factors such as treatment refusal, dropping out of treatment, and inability to use treatment gains outside of therapy… Read more »
Genetic studies of the NMDA regulatory network in OCD including neuroimaging endophenotypes
With growing interest in how glutamate (one of the most important neurotransmitters linked to learning, memory, and mood) and N-methyl-D-aspartate (NMDA; a glutamate receptor in the brain) are connected to… Read more »