Clinical trials performed for FDA registration for OCD in youth typically excluded youth with comorbid conditions. Notably, many young people have both OCD and Tourette syndrome or OCD and ADHD…. Read more »
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Obsessive compulsive disorder in a genetically homogenous population
Some research into the genetics behind OCD attempted to find specific genes that would serve as markers for the disorder. At the time of this study, different expression of the… Read more »
Development and testing of a symptom-specific OCD rating scale
Accurate scales and questionnaires are crucial for assessing whether a person has OCD and how severe the symptoms are. Used by treatment providers and researchers, these assessments provide the first… Read more »
Open-label trial of St. John’s wort (Hypericum perforatum) in obsessive compulsive disorder
St. John’s wort (Hypericum perforatum) is a plant that has been traditionally used in Europe to treat depression, with research demonstrating that it can act like a selective serotonin reuptake… Read more »
Adrenal enzyme disorders define a subtype of OCD that responds to a unique treatment
A risk factor that can predispose some individuals to develop OCD is a group of inherited adrenal gland enzyme disorders that affect the body’s steroid hormone production. Despite the effects… Read more »
A double-blind placebo-controlled trial of tramadol in treatment-refractory OCD
Although selective serotonin reuptake inhibitors (SSRIs) are a treatment for OCD, research at the time of this study showed that 40-50% of OCD patients experienced small or no symptom reduction… Read more »
Functional neuroanatomy of obsessive compulsive hoarding
This study was conducted before hoarding disorder (HD) became a separate diagnosis in the DSM-V in 2013. At the time of the study, research showed that 30% of OCD patients… Read more »
Measurement of the serotonin transporter protein in obsessive compulsive disorder
At the time of this study, there was a hypothesis that dysfunctions in serotonin (a neurotransmitter responsible for mood, cognition, reward, and memory) were associated with OCD; however, this was… Read more »
Efficacy of telephone-administered treatment for OCD
Although a variety of psychotherapies are available to treat OCD, such as the cognitive behavioral therapies (CBT), access to them at the time of this study was not widespread; computers… Read more »
Expressed emotion and family accommodation in OCD: Implications for family behavioral treatment
Family members and close ones of patients with OCD often accommodate their symptoms, which leads to enabling and a lack of improvement. Family support without accommodation is crucial for the… Read more »