Psychotherapies for OCD, such as the cognitive behavior therapies (CBT) and exposure and response prevention (ERP), are typically conducted in a therapist’s office. While we know today that options such… Read more »
A molecular genetic analysis of early-onset obsessive compulsive disorder
At the time of this grant, interest in research on the genetic basis of OCD was growing. With greater understanding of the roles that specific genetic variants play in the… Read more »
Cerebral metabolic predictors of response to paroxetine and risperidone in refractory obsessive compulsive disorder
Positron emission tomography (PET; body scans that measure changes in metabolic processes, blood flow, and other processes) scans have shown increased glucose metabolic rates in the brains of OCD patients,… Read more »
Obsessions and compulsions in mothers with postpartum-onset major depression
Perinatal OCD can focus on the safety and wellbeing of the child, as well as factors surrounding parenting. At the time of this study, little research focused on perinatal OCD… Read more »
Investigation of orbital frontal cortex volume from structural MRI in obsessive compulsive disorder
Functional brain imaging of OCD patients showed abnormalities in the orbitofrontal cortex (OFC; a brain region responsible for decision making which is linked to multiple regions related to emotion, reward,… Read more »
Psychobiology and treatment of SSRI-resistant obsessive compulsive disorder
Although selective serotonin reuptake inhibitors (SSRIs) are an effective treatment option for patients with OCD, research at the time showed that patients experienced a 40-60% reduction in symptoms. 30-40% of… Read more »
Uncluttering: Treatment for hoarding
This study was conducted before hoarding disorder (HD) became a separate diagnosis in the DSM-5 in 2013. At the time, research identified four problems that people with hoarding symptoms had:… Read more »
Single vs. combined pharmacological treatment of children and adolescents with comorbid OCD plus TS
Clinical trials performed for FDA registration for OCD in youth typically excluded youth with comorbid conditions. Notably, many young people have both OCD and Tourette syndrome or OCD and ADHD…. Read more »
Obsessive compulsive disorder in a genetically homogenous population
Some research into the genetics behind OCD attempted to find specific genes that would serve as markers for the disorder. At the time of this study, different expression of the… Read more »
Development and testing of a symptom-specific OCD rating scale
Accurate scales and questionnaires are crucial for assessing whether a person has OCD and how severe the symptoms are. Used by treatment providers and researchers, these assessments provide the first… Read more »