Although pediatric OCD presents its own difficult symptoms, prior research showed that almost half of children with OCD also had a comorbid disruptive behavior disorder. This study by Dr. Sukhodolsky… Read more »
Treatment response in OCD to sertraline and aripiprazole as compared to sertraline and placebo
Although selective serotonin reuptake inhibitors (SSRIs) are effective for treating OCD, they do not reduce OCD symptoms for everyone due to a variety of factors. A potential avenue of boosting… Read more »
Cytokine levels and genes in childhood OCD: A longitudinal study
PANDAS/PANS creates symptoms of OCD that can wax and wane over time. Research at the time showed that patients with PANDAS/PANS are more likely to respond to medications and cognitive… Read more »
Improving treatment outcome in obsessive compulsive disorder: Does a motivational enhancement intervention boost efficacy?
Despite the efficacy of exposure and response prevention (ERP) in treating OCD, factors such as treatment refusal, dropping out of treatment, and inability to use treatment gains outside of therapy… Read more »
Genetic studies of the NMDA regulatory network in OCD including neuroimaging endophenotypes
With growing interest in how glutamate (one of the most important neurotransmitters linked to learning, memory, and mood) and N-methyl-D-aspartate (NMDA; a glutamate receptor in the brain) are connected to… Read more »
A prospective pilot study of perinatal obsessive compulsive symptoms (OCS) and obsessive compulsive disorder (OCD)
Although perinatal and postpartum depression have been well-documented in research at the time of this study, evidence for the development of OCD symptoms during and after pregnancy began to emerge… Read more »
A double-blind, placebo-controlled trial of N-acetylcysteine in SRI-resistant OCD
Although the initial focus of this study by Dr. Coric and his team was how N-acetylcysteine would supplement the effectiveness of serotonin reuptake inhibitors for treating OCD, this research resulted… Read more »
Double-blind trial of acute and intermediate-term dextro-amphetamine versus caffeine augmentations in treatment-resistant OCD
Despite the variety of medication treatments that exist for OCD, some patients do not respond well to them and experience little to no reduction in their symptoms. This study by… Read more »
Diffusion tensor imaging of OCD
Although neuroimaging techniques such as magnetic resonance imaging existed at the time of this study and could take high-quality pictures of the brain, diffusion tensor imaging (DTI) could visualize the… Read more »
Candidate gene study of obsessive compulsive disorder in a US sample
Interest in finding key candidate genes that are associated with the development of OCD was high, as it could help with identifying OCD before it begins and inform treatment. This… Read more »