PANDAS/PANS is associated with neuroinflammation that leads to sudden and acute OCD symptoms developing in children, seemingly overnight. Non-steroidal anti-inflammatory drugs (NSAIDs) like celecoxib (brand name “Celebrex”) are increasingly recommended… Read more »
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Circadian rhythm changes as a predictor of OCD symptom severity and outcome in residential treatment
Problems with sleep — in particular a delayed sleep cycle where a person falls asleep late at night and wakes up in the late morning or early afternoon — have… Read more »
Towards optimal use of internet-delivered interventions for obsessive compulsive disorder
Cognitive behavioral therapy (CBT), including exposure and response prevention (ERP), is a proven and effective treatment for obsessive-compulsive disorder (OCD). However, many people with OCD are unable to access effective… Read more »
Assessing correlates of neuroinflammation in children with PANDAS, obsessive compulsive disorder, and healthy controls using Magnetic Resonance Imaging
Inflammation of the brain is suspected to be present in children with PANDAS, but confirming this hypothesis is difficult. The best tools for revealing brain inflammation expose patients to ionizing… Read more »
Pilot study of the glutamate AMPAR modulator RR-HNK in OCD
Although there are medications that can help people with OCD manage their symptoms, those that are currently available may take up to two to three months to begin working. Additionally,… Read more »
Clinical trial of image-guided low-intensity focused ultrasound pulsation (LIFUP) for the treatment of obsessive compulsive disorder (OCD)
About one in three people with OCD do not get better after trying first-line treatments. For patients with severe, treatment-resistant OCD, Deep Brain Stimulation (DBS) is an effective option, but… Read more »
Intervening on loneliness to reduce object attachment in hoarding disorder: Two randomized controlled pilot studies
People with hoarding disorder (HD) experience strong emotional attachment to their possessions, and extreme difficulty and distress when throwing things away. This can lead to excessive collecting of possessions, with… Read more »
Understanding and treating OCD in older adults
With the population aging globally, the number of older adults with OCD is expected to double within the next 30 years. We currently lack important information about the best possible… Read more »
Using a machine learning approach to identify immune biomarkers associated with PANS/PANDAS
Despite recent research into Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS) and Pediatric Autoimmune Neuropsychiatric Syndrome (PANS), clinicians and researchers often struggle to differentiate childhood OCD and PANDAS/PANS. These… Read more »
A precision medicine approach to OCD treatment: Targeting neuroinflammation
Much prior research has found evidence of brain inflammation’s role in the development of OCD. As a result, anti-inflammatory medications have been suggested as a potential avenue for treating symptoms… Read more »