Past research has shown that people with OCD experience worsened symptoms when under stress. Some stressors are unique to distinct identities and statuses in a larger society. For African Americans… Read more »
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Active avoidance of threat cues and fear extinction in obsessive compulsive disorder
Past research has shown that we can learn to be afraid of things that we encounter, and that we can also modify our fears through exposure. New research has shown… Read more »
A virtual reality study of cognitive biases in body dysmorphic disorder
Previous research has found that people with body dysmorphic disorder (BDD) often assign negative interpretations to neutral or benign social interactions, and may believe that others are judging them or… Read more »
Neural mechanisms of avoidance in exposure and response prevention for OCD
Many patients with OCD who successfully complete ERP treatment experience life-changing improvements in their OCD symptoms. However, as many as 40-50% of patients do not experience a significant recovery. Dr…. Read more »
Identifying the molecular and cellular substrates of OCD using human post-mortem brain
Brain imaging studies in OCD patients have consistently shown abnormal activity in regions involved in decision-making (orbitofrontal cortex [OFC]) and transmission of sensory information (thalamus). The goal of this project… Read more »
Fifer-Grimes, Rebecca
Celecoxib as an adjunct to treatment as usual in childhood-onset OCD: A double-blind randomized controlled trial
PANDAS/PANS is associated with neuroinflammation that leads to sudden and acute OCD symptoms developing in children, seemingly overnight. Non-steroidal anti-inflammatory drugs (NSAIDs) like celecoxib (brand name “Celebrex”) are increasingly recommended… Read more »
Circadian rhythm changes as a predictor of OCD symptom severity and outcome in residential treatment
Problems with sleep — in particular a delayed sleep cycle where a person falls asleep late at night and wakes up in the late morning or early afternoon — have… Read more »
Towards optimal use of internet-delivered interventions for obsessive compulsive disorder
Cognitive behavioral therapy (CBT), including exposure and response prevention (ERP), is a proven and effective treatment for obsessive-compulsive disorder (OCD). However, many people with OCD are unable to access effective… Read more »
Assessing correlates of neuroinflammation in children with PANDAS, obsessive compulsive disorder, and healthy controls using Magnetic Resonance Imaging
Inflammation of the brain is suspected to be present in children with PANDAS, but confirming this hypothesis is difficult. The best tools for revealing brain inflammation expose patients to ionizing… Read more »