Trichotillomania is an OCD-related disorder characterized by compulsive hair pulling, and associated with impaired social functioning and self-esteem. This study by Dr. O’Sullivan and his team proposed using magnetic resonance… Read more »
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Comparing the efficacy of 3 forms of CBT for OCD
Cognitive behavioral therapies (CBT) are a category of treatment that have proven to be effective for treating OCD. CBT includes a variety of modalities, including one-on-one and group therapies. This… Read more »
Are children of adults with OCD at greater risk? Investigating the genetics of OCD
At the time of this grant, research into genetic factors underlying OCD and its comorbidities was still novel. The team led by Drs. Black and Gaffney investigated whether children of… Read more »
Monoclonal D8/17 positivity: A possible peripheral marker for some forms of OCD
Sydenham’s chorea is a type of rheumatic fever that may result from infections like strep throat, and which shares symptoms with OCD and Tourette syndrome. Previous research showed that an… Read more »
Cytokine production in patients with OCD
Chronic and prolonged stress coupled with a long period of grief and despair can lead to an increased vulnerability to illness through their effects on the immune system. As a… Read more »
Efficacy of home-based behavioral therapy for OCD
Psychotherapies for OCD, such as the cognitive behavior therapies (CBT) and exposure and response prevention (ERP), are typically conducted in a therapist’s office. While we know today that options such… Read more »
A molecular genetic analysis of early-onset obsessive compulsive disorder
At the time of this grant, interest in research on the genetic basis of OCD was growing. With greater understanding of the roles that specific genetic variants play in the… Read more »
Cerebral metabolic predictors of response to paroxetine and risperidone in refractory obsessive compulsive disorder
Positron emission tomography (PET; body scans that measure changes in metabolic processes, blood flow, and other processes) scans have shown increased glucose metabolic rates in the brains of OCD patients,… Read more »
Obsessions and compulsions in mothers with postpartum-onset major depression
Perinatal OCD can focus on the safety and wellbeing of the child, as well as factors surrounding parenting. At the time of this study, little research focused on perinatal OCD… Read more »
Investigation of orbital frontal cortex volume from structural MRI in obsessive compulsive disorder
Functional brain imaging of OCD patients showed abnormalities in the orbitofrontal cortex (OFC; a brain region responsible for decision making which is linked to multiple regions related to emotion, reward,… Read more »