At the time of this study, one proposed method by which PANDAS/PANS takes hold in patients is the autoimmune response of antibodies made to fight Group A beta-hemolytic Streptococcus (GABHS;… Read more »
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MRS glutamate-stratified treatment of pediatric OCD
Although cognitive behavioral therapy (CBT) is an effective treatment for pediatric OCD, not all patients respond to it equally — with some seeing little to no decrease in symptoms. This… Read more »
Sleep and circadian disturbances as a vulnerability for OCD
Sleep and circadian rhythms (internal regulators of sleep cycles) are crucial for mental health, and disorders such as insomnia have immensely negative consequences on daily functioning and wellbeing. Studies by… Read more »
PANDAS autoantibodies and the blood-brain barrier
Infections with S. pyogenes (GAS) are associated with brain autoimmune disorders: Sydenham’s chorea (SC) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS). Autoantibodies form when the immune system fails to… Read more »
Explicating the influence of object attachment in hoarding disorder
Even after completing CBT, many patients with hoarding disorder (HD) continue to experience clinically significant hoarding symptoms. While CBT challenges the importance of hoarded objects, it does not address patients’… Read more »
Use of transcranial direct current stimulation to enhance consolidation of therapeutic learning in obsessive-compulsive disorder (OCD)
While medications and psychotherapy can each help about 60% of OCD patients, troubling symptoms can often persist even among treatment responders. New therapeutic strategies are urgently needed. The top therapeutic… Read more »
Decision-making impairments in OCD: An integrated behavioral economics model
Patients with OCD often view risky situations as aversive, with high rates of avoidance of feared situations and stimuli (e.g., public restrooms, kitchen stoves). However, the research on risk aversion… Read more »
The impact of obsessive-compulsive disorder on education, labor market marginalization, and societal cost
OCD typically emerges in childhood or adolescence, may be chronic, and is associated with marked functional impairment, reduced quality of life, and high economic burden for society. The impact of… Read more »
Obsessive-compulsive symptoms in African American young adults: The roles of racial discrimination and racial identity
Past research has shown that people with OCD experience worsened symptoms when under stress. Some stressors are unique to distinct identities and statuses in a larger society. For African Americans… Read more »
Active avoidance of threat cues and fear extinction in obsessive compulsive disorder
Past research has shown that we can learn to be afraid of things that we encounter, and that we can also modify our fears through exposure. New research has shown… Read more »